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Epothilone B HOUSE STANDARD

Epothilone B

CAS: 152044-54-7

Molecular Formula: C27H41NO6S

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Epothilone B HOUSE STANDARD - Names and Identifiers

Name Epothilone B
Synonyms Patupilone
EPOTHILONE
Epothilone B
Epothilone B(EPO906)
Epothilone B(Patupilone)
Epothilone B HOUSE STANDARD
Epothilone B (EPO906, Patupilone)
(3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione
(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
(1S,3S,7R,10S,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Patupilone (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
[1S-[1R*, 3R* (E) , 7R*, 10S*, 11R*, 12R*, 16S*]]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[1-methyl-2-(2-methyl-4-thiazolyl) ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
CAS 152044-54-7
EINECS 604-822-6
InChI InChI=1/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
InChIKey QXRSDHAAWVKZLJ-PVYNADRNSA-N

Epothilone B HOUSE STANDARD - Physico-chemical Properties

Molecular FormulaC27H41NO6S
Molar Mass507.68
Density1.136
Melting Point95-97°C
Boling Point680.2±55.0 °C(Predicted)
Specific Rotation(α)D21 -35° (c = 0.7 in methanol)
Flash Point365.165°C
Solubility Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml).
Vapor Presure0mmHg at 25°C
AppearanceWhite powder
Colorcolorless
pKa13.57±0.70(Predicted)
Storage ConditionStore at -20°C
StabilityStable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
SensitiveSensitive to light
Refractive Index1.532
MDLMFCD02101921
Use(-)-Epomycin B is a stable drug of microtubules (MT), derived from natural myxobacteria Sorangium cellulosum, and is a macrolide anti-tumor factor. The biological characteristics of EpoB and EpoA are similar. However, EpoB is 10 times more effective than EpoA in multidrug-resistant (MDR) cells (IC50=2 nM for MDR CCRF-CEM/VBL100 cells) that express P-glycoprotein. (-)-epothol B is similar to paclitaxel and is an alternative to paclitaxel in cell growth. EpoB leads to cell cycle arrest (IC50=3.5 nM)..
In vitro studyEpothilone B is more active than Epothilone A. Epothilone B has an EC0.01 of 1.8 nM. Epothilone B acted on HCT116 cells and effectively inhibited cell proliferation with an IC50 of 0.8 nM. Epothilone B induces cell cycle arrest in KB3-1, KBV-1, Hela, and Hs578T cells and is cytotoxic with an IC50 of 3 nM to 92 nM. Epothilone B competes with paclitaxel for binding to microtubules with an IC50 of 3.3 μm. 3.5 nM Epothilone B acts on MCF-7 cells overexpressing GFP-α-tubulin, sufficiently inhibiting microtubule dynamics. At the same time, Epothilone B induced mitotic arrest with an IC50 of 3.5 nM. Epothilone B acts on multiple myeloma (MM) cells, including RPMI 8226, U266, MM.1s, LR5, and MR20, and directly inhibits cell proliferation with an IC50 of 1 nM to 10 nM. 10 nM Epothilone B also induced cell cycle arrest and apoptosis. Recent studies have shown that 5 nM-100 nM Epothilone B acts on ovarian cancer Hey cells to enhance surface epithelial cell adhesion antigen (EpCAM).
In vivo studyEpothilone B at a dose of 2.5 mg/kg-4 mg/kg in mice bearing RPMI 8226 cell xenografts prolongs the life of mice and inhibits tumor growth. Epothilone B also inhibited tumor growth in mice bearing xenografts of prostate cancer cells, including DU145 and PC3.

Epothilone B HOUSE STANDARD - Risk and Safety

WGK Germany3
HS Code29419090
Epothilone B HOUSE STANDARD
Supplier List
Shanghai Amole Biotechnology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Request for quotation
CAS: 152044-54-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
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SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Epothilone B Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
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MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: EPO 906; Patupilone Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Multiple SpecificationsSpot supply
Product Name: Epothilone B? Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
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Wechat: chinaskyrun
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Epothilone B Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Shanghai Amole Biotechnology Co., Ltd.
Multiple SpecificationsSpot supply
Product Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Request for quotation
CAS: 152044-54-7
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365 Click to send a QQ message
Wechat: 18916960931
SHANGHAI ACMEC BIOCHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: Epothilone B Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922 Click to send a QQ message
Wechat: 18621343501
WhatsApp: +86-18621343501
MedChemExpress (MCE)
Multiple SpecificationsSpot supply
Product Name: EPO 906; Patupilone Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Multiple SpecificationsSpot supply
Product Name: Epothilone B? Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Epothilone B Visit Supplier Webpage Request for quotation
CAS: 152044-54-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
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Epothilone B HOUSE STANDARD
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